Research Article
GC-MS and Cellular Toxicity Studies on Smokeless-Tobacco Show Alerting Cytotoxic effect on Human Gingiva and Lung Fibroblasts
Table 4
Selectivity of the eleven SLT extracts and doxorubicin against HT29 and HepG2 cancer cells compared with hGF and MRC5 normal cells.
| Sample | hGF | MRC5 | Average SI | HT29 | HepG2 | HT29 | HepG2 |
| S1 | 0.67 | 1.14 | 0.05 | 0.09 | 0.48 | S2 | 0.34 | 0.38 | 0.59 | 0.67 | 0.49 | S3 | 0.64 | 0.34 | 0.14 | 0.07 | 0.29 | S4 | 0.00 | 0.00 | 0.02 | 0.01 | 0.00 | S5 | 0.38 | 0.37 | 0.05 | 0.05 | 0.21 | S6 | 0.09 | 0.02 | 0.03 | 0.00 | 0.03 | S7 | 0.17 | 0.15 | 0.29 | 0.27 | 0.22 | S8 | 0.49 | 0.09 | 0.73 | 0.14 | 0.36 | S9 | 0.03 | 0.02 | 0.86 | 0.76 | 0.41 | S10 | 0.00 | 0.00 | 0.01 | 0.01 | 0.00 | S11 | 0.17 | 0.13 | 0.26 | 0.21 | 0.19 | Doxorubicin | 3.84 | 3.59 | 3.11 | 2.91 | 3.36 |
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<1, nonselective effect against the normal cell.
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