Development of UV Spectrophotometric Procedures for Determination of Amlodipine and Celecoxib in Formulation: Use of Scaling Factor to Improve the Sensitivity
Table 2
Precision and accuracy data.
Amount of drug (μg/mL)
Interday
Intraday
Amount found mean (n = 3) ± SD
% RSD
% RE
Amount found mean (n = 9) ± SD
% RSD
% RE
First derivative method
AMD
1
1.01 ± 0.01
0.51
0.99
0.99 ± 0.01
1.02
−1.01
4
3.93 ± 0.05
0.41
−1.78
4.01 ± 0.04
1.00
0.25
8
7.94 ± 0.18
1.88
−0.76
7.9 ± 0.15
1.90
−1.27
5
4.96 ± 0.05
1.01
−0.81
5.08 ± 0.06
1.18
1.57
COX
20
20.16 ± 0.38
1.51
0.79
19.76 ± 0.31
1.58
−1.25
40
39.4 ± 0.66
1.7
−1.52
40.08 ± 0.59
1.47
0.20
Second method
AMD
1
0.99 ± 0.01
1.02
−1.01
0.98 ± 0.01
1.02
−2.00
4
4.06 ± 0.07
1.14
1.48
3.94 ± 0.06
2.04
−2.04
8
7.92 ± 0.14
1.97
−1.01
7.86 ± 0.17
2.16
−1.78
COX
5
4.91 ± 0.03
1.01
−1.83
5.04 ± 0.07
1.39
0.79
20
19.67 ± 0.21
1.39
−1.68
19.81 ± 0.33
1.67
−0.96
40
39.85 ± 0.71
1.33
−0.38
39.4 ± 0.69
1.75
−1.52
SD: standard deviation; % RSD: percent relative standard deviation; % RE: percent relative error.
