Development of UV Spectrophotometric Procedures for Determination of Amlodipine and Celecoxib in Formulation: Use of Scaling Factor to Improve the Sensitivity

Table 1

Regression equations and validation parameters results for AMD and COX.

Parameters	First derivative method		Second method
Drugs	AMD	COX	AMD	COX
Wave length (nm)	−252.0	−289.4	363.4	−286.7
Linearity range (μg/ml)	0.5–10	5–40	1–10	5–40
LOD (μg/ml)	0.14	0.45	0.31	0.34
LOQ (μg/ml)	0.42	1.24	0.92	0.99
Slop (m)	0.0157	0.0079	0.0151	0.1753
Intercept (c)	0.0004	−0.0004	0.0006	−0.0947
Correlation coefficient (r^2)	0.9992	0.9990	0.9985	0.9991