Review Article

The Effects of Strength Training Combined with Vitamin C and E Supplementation on Skeletal Muscle Mass and Strength: A Systematic Review and Meta-Analysis

Table 1

Main characteristics and findings of the selected studies.

StudyPEDro scoreSampleTrainingDurationVitaminsStrengthHypertrophy

Bobeuf et al. [29]10n = 48 sedentary men and women (±65.5 y)3x/wk; 7 exercises; 3 sets, 8 reps; 80% 1 RM; sit-ups included6 months600 mg/d vitamin E; 1000 mg/d vitamin CData unavailableFat-free mass gain (+1.5 kg) only in RT plus supplementation group

Bobeuf et al. [28]10n = 57 sedentary men and women (±65.3 y)3x/wk; 7 exercises; 3 sets, 8 reps; 80% 1 RM; sit-ups included6 months600 mg/day vitamin E; 1000 mg/d vitamin CSignificant and similar % 1 RM increase in RT (+65.0%) and RT plus supplementation (+78.2%)Fat-free mass gain NS between RT (+0.3 kg) and RT plus supplementation (+0.5 kg)

Theodorou et al. [34]9n = 28 trained men (±25.6 y in placebo, ±26.2 y in vitamins)Isokinetic eccentric; 2x/wk; 5 sets; 15 reps; 60°/s; seated position11 weeks with 4 weeks of training1000 mg/d vitamin C; 400 IU/d vitamin E for 11 weeksIsometric peak torque increased similarly (15% in placebo; 18% in vitamins) in both groupsData unavailable

Paulsen et al. [32]9n = 32 trained men and women (±27.0 y in vitamins, ±24.0 y in placebo)Traditional, progressive ST; 4x/wk; 3 to 4 sets; 6 to 7 exercises; 11 to 6 RM10 weeks1000 mg/d vitamin C; 235 mg/d vitamin E% 1 RM gain in bíceps curl greater in placebo group (+17.1 vs. +7.6); isometric force gain only in the placebo groupCSA of upper (8.5 vs. 7.6%) and lower limbs (both 3.8%) increased similarly in vitamins and placebo groups The same for LBM
Bjørnsen et al. [30]9n = 34 sedentary elderly men (±68.0 years)Free weight exercises; weekly undulating periodization; 3x/wk12 weeks1000 mg/d vitamin C; 235 mg/d vitamin ESignificant and similar 1 RM increase in placebo and antioxidants groupsRectus femoris thickness increased more in placebo (+3.4 vs. +1.9 mm). The same for LBM (2.2 vs. 0.87 kg)

Yfanti et al. [35]8n = 16 trained men (±24.6 y in vitamins, ±25.9 y in control)Isokinetic eccentric; 2x/wk; 5 sets; 2 min rest; 15 reps; 60°/s in seated position9 weeks with 4 weeks of training1000 mg/d vitamin C; 400 IU/d vitamin E for 9 weeksSignificant and similar peak torque increase in placebo (+6.6%) and vitamins group (7.9%)Data unavailable

Dutra et al. [33]8n = 42 untrained women (±23.7 y in vitamins, ±24.0 y in placebo, ±23.6 y in control)Traditional, progressive ST; 2x/wk; 2 to 4 sets; 4 exercises; 12 to 8 RM10 weeks1000 mg/d vitamin C; 400 IU/d vitamin E for 70 daysSignificant peak torque increases in placebo and vitamins. Only placebo was different when compared with control
Rectus femoris thickness increased similarly in placebo (39.7 to 42.5 mm) and vitamins group (37.2 to 40.3 mm)

RT: resistance training; y: years; wk: week; CSA: cross-sectional area; LBM: lean body mass; RM: repetition maximum.