Journal of Skin Cancer

Review Article

Patched Knockout Mouse Models of Basal Cell Carcinoma

Table 1

Ptch knockout mouse models for preclinical BCC treatment studies.
BCC modelMode of BCC inductionTreatmentReference
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + UVCyclopamine[60]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + skin punchesUVCUR61414[61]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + UVα-difluoromethylornithine[62]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + IR/UVTazarotene[55]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + UVTazarotene, ATRA, AGN195813, AGN194204, AGN194310[63]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + IR/UVCelecoxib, sulindac, MF-tricyclic[64]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + UVGreen/black tea[54]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + K14-Cre-ER p53fl/flIR and conditional p53 ablationCUR61414[65]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + K14-Cre-ER p53fl/flIR and conditional p53 ablationItraconazole[66]
𝑃 𝑡 𝑐 ℎ 𝑛 𝑒 𝑜 1 2 / + K14-Cre-ER p53fl/flIR and conditional p53 ablationVitamin D3[67]
𝑃 𝑡 𝑐 ℎ 𝑓 𝑙 𝑜 𝑥 / 𝑓 𝑙 𝑜 𝑥 𝐸 𝑅 𝑇 2 + / − conditional Ptch ablationCalcitriol[68]
UV: ultraviolet radiation; IR: ionizing radiation.