Patched Knockout Mouse Models of Basal Cell Carcinoma
Figure 1
Features of BCC in and mice. animals were bred with the mouse lines ERT2 or . The respective Ptch flox/+ and mice were backcrossed to mice to obtain and mice. ERT2 or was activated by one intramuscular (i.m.) injection of 100 μg tamoxifen as described recently [20, 85], or by intraperitoneal injections of 1 mg tamoxifen (10 μg/μL in sterile ethanol/sun flower oil 1 : 25) for 5 consecutive days (see [88]), respectively. Genotyping of the , , ERT2, and alleles was performed as described recently [20, 84, 85]. All mice used in the study were handled in accordance with the German animal protection law. (a) shows the appearance and histology of skin from control and tamoxifen-treated mice and (b) shows that of control and tamoxifen-treated mice.