Electric Cell-Substrate Impedance Sensing of Cellular Effects under Hypoxic Conditions and Carbonic Anhydrase Inhibition

<div>(a) Simplified equivalent circuit for assessing EIS data on HT-29 cell monolayers: constant phase element (CPE) for the cell monolayer-electrode interface, <i>R</i><sub>p</sub> resistor that defines the paracellular route in parallel with a capacitor (<i>C</i><sub>c</sub>) which describes the cellular monolayer and a resistor for the bulk solution (<i>R</i><sub>sol</sub>). (b) Complex impedance spectra, modulus, and phase, comparison between characteristic experimental values and fit.</div>

Journal of Sensors

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Figure 2

Figure 2: Electric Cell-Substrate Impedance Sensing of Cellular Effects under Hypoxic Conditions and Carbonic Anhydrase Inhibition 