A Bayesian Adaptive Design in Cancer Phase I Trials Using Dose Combinations in the Presence of a Baseline Covariate

Table 2

A selected dose limiting toxicity scenario with for considering discrete dose combinations. True MTDs are shown in bold.

Dose level	Z = 0					Z = 1
	1	2	3	4	5	1	2	3	4	5
5	0.25	0.33	0.40	0.48	0.70	0.45	0.53	0.60	0.68	0.90
4	0.20	0.26	0.33	0.43	0.55	0.40	0.46	0.53	0.63	0.75
3	0.13	0.16	0.24	0.33	0.39	0.33	0.36	0.44	0.53	0.59
2	0.05	0.13	0.18	0.28	0.33	0.25	0.33	0.38	0.48	0.53
1	0.001	0.05	0.13	0.20	0.27	0.201	0.25	0.33	0.40	0.47