Antimalarial Efficacy and Toxicological Assessment of Extracts of Some Ghanaian Medicinal Plants
Table 4
Cytotoxicity of crude extracts in LLC-MK2 cells and selectivity index (SI) values in the three tested Plasmodium falciparum strains.
Extract
CC50 on LLC-MK2 (μg/mL)
Selectivity Index (SI)
FCB
W2
CAM06
Paspalum scrobiculatum
157.1 ± 0.98
6.54
23.77
9.63
Bidens pilosa
102.2 ± 0.86
4.34
22.17
4.76
Acridocarpus alternifolius
> 1,000
23.74
48.23
27.02
Clappertonia ficifolia
273.5 ± 2.02
61.74
34.45
41.69
Mitragyna ciliata
262.7 ± 1.66
11.61
14.09
5.40
Parinari congensis
150.6 ± 1.27
12.05
2.92
3.34
Monanthotaxis caffra
88.6 ± 0.46
15.12
4.68
4.78
Datura stramonium
> 1,000
128.65
14.63
37.09
Faurea speciosa
154.9 ± 7.89
10.45
16.64
22.29
Syzygium guineense
77.9 ± 0.71
5.21
16.86
14.06
Croton penduliflorus Hutch
272.0 ± 2.02
50.65
19.39
18.55
Gleevec (Imatinib)
18.50 ± 1.21
CC50, = cytotoxic concentration 50%. Mean and standard deviation values of CC50 were generated from three replicate experiments. CC50 < 5: highly toxic; 5 < CC50 <10: cytotoxic; 10 < CC50 < 30: moderately to weakly cytotoxic; and CC50 > 30: noncytotoxic [17].
