Association of PLGA Microspheres to Carrier Pellets by Fluid Bed Coating: A Novel Approach towards Improving the Flowability of Microparticles

Figure 7

(Top) Plots correlating the number of immersions to the percentage of detached microspheres from the coated pellets (left graph) and to the average diameter of the particles (right graph; note: lines for microspheres-coated pellets and suspended microspheres overlapped). (Bottom) Schematic representation of the behavior of microspheres-coated pellets in contact with aqueous media. Coating polymer readily dissolves releasing disaggregated microspheres.