Research Article
Cocoa Pod Husk Pectin Intended as a Pharmaceutical Excipient Has No Adverse Effects on Haematological Parameters in Sprague Dawley Rats
Table 2
Results showing the effect of CPH pectin on red blood cell indices of male rats.
| Red blood cell indices | Day | Control | Low dose 0.714 mg/kg | Medium dose 7.14 mg/kg | High dose 71.4 mg/kg |
| RBC (x 106/ul) | 30 | 8.72±0.09 | 9.16±0.23 | 8.93±0.14 | 8.91±0.13 | 60 | 8.78±0.07 | 8.68±0.12 | 8.58±0.18 | 8.60±0.11 | 90 | 9.03±0.11 | 8.90±0.12 | 8.77±0.15 | 8.91±0.14 |
| HGB (g/dl) | 30 | 15.00±0.18 | 15.52±0.36 | 15.63±0.43 | 15.48±0.16 | 60 | 15.37±0.20 | 15.18±0.34 | 15.03±0.22 | 15.08±0.12 | 90 | 15.50±0.13 | 15.38±0.34 | 15.35±0.27 | 15.35±0.18 |
| HCT (%) | 30 | 49.47±0.59 | 49.68±0.68 | 49.87±1.07 | 48.52±0.61 | 60 | 47.48±0.67 | 47.10±1.21 | 45.87±0.83 | 46.88±0.68 | 90 | 48.82±0.44 | 49.97±0.97 | 47.62±0.88 | 50.30±0.78 |
| MCV (fl) | 30 | 55.60±0.19 | 54.92±0.62 | 52.95±0.26 | 53.73±0.35 | 60 | 53.20±0.31 | 52.65±0.57 | 53.50±0.36 | 54.23±0.40 | 90 | 54.08±0.70 | 53.50±1.11 | 54.83±0.53 | 55.88±0.49 |
| MCH (pg) | 30 | 17.08±0.18 | 16.93±0.26 | 16.98±0.22 | 17.15±0.13 | 60 | 17.32±0.11 | 17.10±0.26 | 17.52±0.16 | 17.55±0.12 | 90 | 17.05±0.11 | 16.92±0.21 | 17.47±0.39 | 17.47±0.11 |
| MCHC (g/dl) | 30 | 30.63±0.25 | 30.53±0.18 | 31.90±0.19 | 31.63±0.12 | 60 | 32.37±0.13 | 32.23±0.19 | 32.80±0.16 | 32.18±0.29 | 90 | 31.83±0.12 | 31.22±0.59 | 31.60±0.85 | 30.90±0.18 |
| RDW-SD (fl) | 30 | 29.55±0.26 | 29.55±0.30 | 28.00±0.39 | 27.75±0.40 | 60 | 27.50±0.24 | 27.03±0.27 | 27.52±0.07 | 27.68±0.31 | 90 | 28.55±0.91 | 29.87±1.28 | 28.23±0.76 | 29.83±0.45 |
| RDW-CV (%) | 30 | 13.55±0.56 | 14.70±0.77 | 14.57±0.38 | 12.53±0.39 | 60 | 13.03±0.63 | 13.08±0.58 | 13.12±0.33 | 13.03±0.36 | 90 | 14.30±1.14 | 15.33±1.40 | 13.57±0.57 | 13.58±0.50 |
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Significantly different ( < 0.01) |