Research Article
Formulation and Evaluation of Multilayered Tablets of Pioglitazone Hydrochloride and Metformin Hydrochloride
Table 8
Release kinetics of metformin HCl controlled release layer (F5–F13).
| Batch number | Zero order | Higuchi | Korsmeyer-Peppas model | First order | | | | | | - | | | |
| F5 | 0.9018 | 17.42 | 0.9924 | 42.15 | 0.3179 | 1.995 | 0.300 | 0.0098 | 0.0806 | F6 | 0.9075 | 14.56 | 0.9966 | 39.21 | 0.1962 | 1.5995 | 0.204 | 0.0362 | 0.1105 | F7 | 0.9533 | 10.28 | 0.9681 | 31.57 | 0.4287 | 1.8407 | 0.265 | 0.4647 | 0.2118 | F8 | 0.9594 | 9.99 | 0.9749 | 30.69 | 0.4556 | 1.8155 | 0.259 | 0.4866 | 0.1865 | F9 | 0.9511 | 18.14 | 0.9851 | 42.59 | 0.2937 | 1.9319 | 0.286 | 0.0138 | 0.1381 | F10 | 0.8524 | 11.80 | 0.9856 | 35.75 | 0.0456 | 1.2217 | 0.087 | 0.0698 | 0.1450 | F11 | 0.9062 | 10.30 | 0.9960 | 32.93 | 0.1318 | 1.1825 | 0.120 | 0.3679 | 0.2533 | F12 | 0.9044 | 9.44 | 0.9878 | 30.09 | 0.2408 | 1.4256 | 0.154 | 0.4158 | 0.1888 | F13 | 0.9932 | 9.66 | 0.9525 | 31.25 | 0.1307 | 1.6749 | 0.224 | 0.3698 | 0.2809 |
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