Development of Budesonide Loaded Biopolymer Based Dry Powder Inhaler: Optimization, In Vitro Deposition, and Cytotoxicity Study

Table 3

Flowability characteristics of budesonide DPI.

Formulations	Angle of repose^a  [𝜃]	Bulk density^a  [g/cm^3]	Tapped density^a  [g/cm^3]	Carr’s index^a  [Ci%]	Hausner ratio^a	Percentage porosity^a
F1	26 ± 0.01	0.084 ± 0.04	0.105 ± 0.05	20.00 ± 0.04	0.80 ± 0.09	20 ± 0.04
F2	26 ± 0.07	0.071 ± 0.02	0.123 ± 0.02	42.27 ± 0.02	0.57 ± 0.08	43 ± 0.07
F3	24 ± 0.04	0.123 ± 0.03	0.129 ± 0.04	04.65 ± 0.01	0.95 ± 0.08	10 ± 0.05
F4	27 ± 0.01	0.097 ± 0.02	0.131 ± 0.07	25.95 ± 0.03	0.74 ± 0.01	26 ± 0.02
F5	25 ± 0.02	0.101 ± 0.07	0.124 ± 0.02	18.54 ± 0.05	0.81 ± 0.03	19 ± 0.01
F6	24 ± 0.09	0.073 ± 0.02	0.089 ± 0.01	17.97 ± 0.03	0.80 ± 0.04	18 ± 0.08
F7	25 ± 0.06	0.076 ± 0.08	0.095 ± 0.02	20.00 ± 0.02	0.80 ± 0.10	20 ± 0.03
F8	28 ± 0.02	0.079 ± 0.02	0.124 ± 0.03	36.29 ± 0.03	0.63 ± 0.03	37 ± 0.06
F9	26 ± 0.05	0.037 ± 0.06	0.071 ± 0.02	47.88 ± 0.07	0.52 ± 0.08	48 ± 0.04
Commercial DPI	24 ± 0.07	0.124 ± 0.05	0.154 ± 0.09	19.48 ± 0.03	0.80 ± 0.04	20 ± 0.04

aAll the determinations performed in triplicate and values are expressed as mean (values = average ± SD).