Review Article
Microbicides for the Treatment of Sexually Transmitted HIV Infections
Table 9
New preclinical microbicide candidates with their mechanism of action.
| Mechanism of action | Candidates |
| Vaginal defense enhancer | Genetically engineered probiotics, mucocept HIV, RANTES peptides, and Lactobacillus delivered cyanovirin-N |
| Entry/fussion inhibitors | Aptamers, betacyclodextrin, flavinoids, porphyrins, siRNA, silver nanoparticles, ISIS 5060, reterocyclines, and TatCD |
| Combination approaches | Buffer gel with dendrimers, M167, BMS, and other ARV |
| Microbicide combined with devices | Duet cervical barrier and condoms with alkyl sulfate coating |
| Uncharacterized mechanism | CO (ciclo piroxolamine) |
| Surfactants | Alkyl sulfates (surfactants and chaotropic agents) |
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