Demonstrated that WHI-07 either alone or in combination with a vanadocene has clinical potential for the development of a dual-function anti-HIV microbicide for sexually active women [23].
Tragacanth gum, aacacia gum
Miconazole nitrate (vaginal suspension)
Exhibit uniformly distribution of drug and show locally effect to control the infection [24].
Polycarbophil, carbopol 974P
Tenofovir (TFV), IQP-0528 (vaginal gel)
These gels have the potential for dual compartment use to inhibit the virus entry [25].
Pluronic
Metronidazole (vaginal gel)
Successfully used for treatment of bacterial vaginosis [26].
Cellulose acetate phthalate (CAP)
Model drug (vaginal cream)
Use as a topical microbicide for preventing HIV-1 infection in humans [27].
Hydroxyethyl cellulose
Tenofovir (vaginal gel)
Exhibit excellent effectiveness in preventing human immunodeficiency virus transmission [28].
Hydroxyethyl cellulose
Tenofovir (vaginal ring)
Exhibit potential for the prevention of transmission of (HIV-1) in pig-tailed macaques [29].