Research Article
Solubility Enhancement of Budesonide and Statistical Optimization of Coating Variables for Targeted Drug Delivery
Table 2
Coating composition of factorial batches (B1 to B11).
| Ingredients | Eudragit S100 (g) | Eudragit L100 (g) | Dibutyl phthalate (mL) (10% of total polymer weight) | Isopropyl alcohol (mL) | Acetone (mL) | % weight gain (coating) |
| B1 | — | 3 | 0.3 | 10 | 10 | 5 | B2 | 1.5 | 1.5 | 0.3 | 10 | 10 | 5 | B3 | 3 | — | 0.3 | 10 | 10 | 5 | B4 | — | 3 | 0.3 | 10 | 10 | 7.5 | B5 | 1.5 | 1.5 | 0.3 | 10 | 10 | 7.5 | B6 | 3 | — | 0.3 | 10 | 10 | 7.5 | B7 | — | 3 | 0.3 | 10 | 10 | 10 | B8 | 1.5 | 1.5 | 0.3 | 10 | 10 | 10 | B9 | 3 | — | 0.3 | 10 | 10 | 10 | B10* | 1.5 | 1.5 | 0.3 | 10 | 10 | 7.5 | B11* | 1.5 | 1.5 | 0.3 | 10 | 10 | 7.5 |
|
|
Center point batches.
|