SARS-CoV-2, Early Entry Events

Table 1

CoV S protein recognition elements.

Host receptor	Substrate-ligand	CoV S ligand (RBD)^a
CD13^b [8]	Terminal amines	S1-CTD^c
DPP4^d [9]	Terminal amines	S1-CTD
CEACAM1^e [10]	Cell-cell adhesion lectin	S1-NTD^f
Neuraminic acid [11]	Cell, viral lectins	S1-NTD
ACE2^g [12]	Angiotensin	S1-CTD
APN^h [13]	Terminal amines	S1-CTD

^aS-protein receptor-binding domain, ^bMetalloprotease, ^cS-protein C-terminal domain, ^dDipeptidase, ^eCarcinoembryonic antigen-related cell adhesion molecule 1, ^fS-protein N-terminal domain, ^gAngiotensin-converting enzyme 2, ^hAminopeptidase N, [] = reference.