SARS-CoV-2, Early Entry Events

Figure 2

SARS-CoV-2 host cell entry. Entry begins with S protein binding to the host cell ACE2 receptor. (a) Endocytosis-mediated entry entails S protein priming/activation reactions occurring in the endosome/endolysosome. (b) Direct fusion entry is mediated by furin and/or TMPRSS-2 as well as other trypsin-like proteases. Taken from Al-Horani, R. A., Kar, S., and Aliter, K. F., Int. J. Mol. Sci., vol 21 (15), 5224, 2020.