Journal of Pathogens

Review Article

Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Table 5

Significantly enriched KEGG pathways within the overlapping interactome/susceptibility gene datasets (Immune related, other diseases and infections). values from the CPDB analysis are provided after each pathway description.


	Immune and defence	Diseases	Other infections

ADHD	None	None	None

Autism	Intestinal immune network for IgA production 0.00138 Hematopoietic cell lineage 0.00196 T cell receptor signalling pathway 0.00439 Fc epsilon RI signalling pathway 0.00838	Dilated cardiomyopathy 0.000293 Arrhythmogenic right ventricular cardiomyopathy (ARVC) 0.000899 Hypertrophic cardiomyopathy (HCM) 0.00151 Viral myocarditis 0.00548	Leishmaniasis 0.00605

Anorexia	None	None	None

Childhood obesity	Intestinal immune network for IgA production 0.00417 NOD-like receptor signalling pathway 0.00604	Graft-versus-host disease 0.0000725 Type I diabetes mellitus 0.0000837 Transcriptional misregulation in cancer 0.000397 Rheumatoid arthritis 0.000774 Allograft rejection 0.0025 Type II diabetes mellitus 0.00417 Alzheimer’s disease 0.00426	Chagas disease (American trypanosomiasis) 0.00114 African trypanosomiasis 0.00223 Malaria 0.0047 Legionellosis 0.00544 Herpes simplex infection 0.0056 Pertussis 0.00968

Depression	Cytokine-cytokine receptor interaction 0.0000494 NOD-like receptor signalling pathway 0.000203 Hematopoietic cell lineage 0.000998	Rheumatoid arthritis 0.000006 Graft-versus-host disease 0.0000516 Alzheimer’s disease 0.000173 Allograft rejection 0.000845	Leishmaniasis 0.0000000000696 Malaria 0.000000000132 African trypanosomiasis 0.000000000337
	Intestinal immune network for IgA production 0.00181 T cell receptor signalling pathway 0.00199 Antigen processing and presentation 0.00665 Fc epsilon RI signalling pathway 0.00741	Type I diabetes mellitus 0.00131 Amyotrophic lateral sclerosis (ALS) 0.00215 Pathways in cancer 0.006 Hypertrophic cardiomyopathy (HCM) 0.00848 Small cell lung cancer 0.00965	Chagas disease (American trypanosomiasis) 0.00000000199 Tuberculosis 0.0000000149 Amoebiasis 0.0000000505 Legionellosis 0.00000786
			Influenza A 0.0000249 Herpes simplex infection 0.0000333 Pertussis 0.0000338 Toxoplasmosis 0.0000548 Salmonella infection 0.000916 HTLV-I infection 0.00202 Measles 0.00463

Bipolar disorder	T cell receptor signalling pathway 0.0000000071 NOD-like receptor signalling pathway 0.0000794 Cytokine-cytokine receptor interaction 0.000951 Antigen processing and presentation 0.00275 Fc epsilon RI signalling pathway 0.00317 Natural killer cell mediated cytotoxicity 0.00379 Toll-like receptor signalling pathway 0.00784	Prostate cancer 0.0000601 Pathways in cancer 0.000895 Osteoclast differentiation 0.00000583 Amyotrophic lateral sclerosis (ALS) 0.0000424 Rheumatoid arthritis 0.0000681 Prion diseases 0.000142 Graft-versus-host disease 0.000266 Alzheimer’s disease 0.000268 Allograft rejection 0.00283 Type I diabetes mellitus 0.00435	Malaria 0.000000108 Tuberculosis 0.000000925 Chagas disease (American trypanosomiasis) 0.00000122 African trypanosomiasis 0.00000646 Measles 0.0000734 HTLV-I infection 0.000178 Influenza A 0.000371 Amoebiasis 0.00132 Leishmaniasis 0.00226 Pertussis 0.0025 Herpes simplex infection 0.00273 Toxoplasmosis 0.00368 Legionellosis 0.00867

Schizophrenia	Cytokine-cytokine receptor interaction 0.000000000286 T cell receptor signalling pathway 0.000000000429	Type I diabetes mellitus 0.00000000983 Allograft rejection 0.0000000512 Graft-versus-host	Leishmaniasis 0.0000000000322 Tuberculosis 0.000000000102 Pertussis 0.000000000705
	NOD-like receptor signalling pathway 0.0000216 Hematopoietic cell lineage 0.0000452 Fc epsilon RI signalling pathway 0.000161 Adipocytokine signalling pathway 0.00053 Intestinal immune network for IgA production 0.000682	disease 0.000000121 Rheumatoid arthritis 0.00000747 Amyotrophic lateral sclerosis (ALS) 0.000009 Asthma 0.00007 Autoimmune thyroid disease 0.0001 Alzheimer’s disease 0.0007	African trypanosomiasis 0.000000032 Chagas disease (American trypanosomiasis) 0.000000038 HTLV-I infection 0.000000319 Salmonella infection 0.000000504
	Toll-like receptor signalling pathway 0.000773 Antigen processing and presentation 0.000887 Cytosolic DNA-sensing pathway 0.00218 Natural killer cell mediated cytotoxicity 0.00387 RIG-I-like receptor signalling pathway 0.00395 B cell receptor signalling pathway 0.00472	Systemic lupus erythematosus 0.0009 Transcriptional misregulation in cancer 0.001 Prion diseases 0.001 Prostate cancer 0.002 Pathways in cancer 0.003 Acute myeloid leukaemia 0.0099	Measles 0.000000634 Legionellosis 0.00000129 Influenza A 0.0000017 Toxoplasmosis 0.00000446 Herpes simplex infection 0.0000156 Amoebiasis 0.0000259 Malaria 0.000099 Staphylococcus aureus infection 0.000152 Viral myocarditis 0.00372

Multiple sclerosis	Cytokine-cytokine receptor interaction 1.02E‒28 Toll-like receptor signalling pathway 0.000000000000000132	Allograft rejection 0.000000000000000147 Type I diabetes mellitus 0.0000000000000549 Rheumatoid arthritis	Chagas disease (American trypanosomiasis) Influenza A Toxoplasmosis
Multiple sclerosis		Chemokine signalling pathway 0.000000000000747 Intestinal immune network for IgA production 0.000000000007 T cell receptor signalling pathway 0.0000000000237	0.000000000000153 Graft-versus-host disease 0.0000000000336 Autoimmune thyroid disease 0.000000000425 Pathways in cancer 0.0000000102
	NOD-like receptor signalling pathway 0.0000000000639 Hematopoietic cell lineage 0.000000000469	Systemic lupus erythematosus 0.000000625 Prion diseases 0.00000316 Alzheimer’s disease 0.00000422	Pertussis 0.000000000000006 Herpes simplex infection 0.0000000000000315
	Natural killer cell mediated cytotoxicity 0.00000058 RIG-I-like receptor signalling pathway 0.00000188	Transcriptional misregulation in cancer 0.00000875 Asthma 0.0000253 Small cell lung cancer 0.000078	African trypanosomiasis 0.00000000000585 Malaria 0.0000000000143
	Primary immunodeficiency 0.00000316 Antigen processing and presentation 0.0000325 Leukocyte transendothelial migration 0.0000719	Colorectal cancer 0.0000921 Bladder cancer 0.000135 Amyotrophic lateral sclerosis (ALS) 0.000341 Prostate cancer 0.00067	Amoebiasis 0.0000000000237 Legionellosis 0.0000000000346 Viral myocarditis 0.0000000089 Salmonella infection 0.0000000677
	Cytosolic DNA-sensing pathway 0.0000921 Complement and coagulation cascades 0.00927 Adipocytokine signalling pathway 0.00927	Pancreatic cancer 0.00147 Chronic myeloid leukaemia 0.00177 Endometrial cancer 0.00339 Acute myeloid leukaemia 0.00473 Thyroid cancer 0.00487	HTLV-I infection 0.000000512 Hepatitis C 0.000000538 Staphylococcus aureus infection 0.00000371 Shigellosis 0.000786 Epithelial cell signalling in Helicobacter pylori infection 0.00882

Alzheimer’s	Hematopoietic cell lineage 0.000000276 Complement and coagulation cascades 0.00000049 Toll-like receptor signalling pathway 0.000000982 NOD-like receptor signalling pathway 0.000002 Cytokine-cytokine receptor interaction 0.000003	Rheumatoid arthritis 0.0000000000000007 Alzheimer’s disease 0.000000013 Graft-versus-host disease 0.0000035 Type I diabetes mellitus 0.000076 Prion diseases 0.000442 Transcriptional misregulation in cancer 0.00049	Malaria 6.05E ‒ 17 Chagas disease (American trypanosomiasis) 0.00000000004 Pertussis 0.000000000204 Leishmaniasis 0.00000000283 Tuberculosis 0.00000000325 Legionellosis 0.00000000407
Alzheimer’s	Cytosolic DNA-sensing pathway 0.000436 Phagosome 0.00098 Intestinal immune network for IgA production 0.00148 Adipocytokine signalling pathway 0.00558	Allograft rejection 0.000549 Hypertrophic cardiomyopathy (HCM) 0.00165 Pathways in cancer 0.00205 Systemic lupus erythematosus 0.00281	Influenza A 0.0000000246 African trypanosomiasis 0.0000000547 Amoebiasis 0.000000126 Salmonella infection 0.000000226

Parkinson’s	NOD-like receptor signalling pathway 0.00000539 Toll-like receptor signalling pathway 0.00000543 Hematopoietic cell lineage 0.0000417 Cytokine-cytokine receptor interaction 0.000153 T cell receptor signalling pathway 0.00123 Intestinal immune network for IgA production 0.00125 Cytosolic DNA-sensing pathway 0.00261 Complement and coagulation cascades 0.00354 Antigen processing and presentation 0.00465 Chemokine signalling pathway 0.00977	Rheumatoid arthritis 0.000000131 Graft-versus-host disease 0.000000932 Type I diabetes mellitus 0.00000119 Asthma 0.00031 Systemic lupus erythematosus 0.000327 Prion diseases 0.000491 Allograft rejection 0.00058 Alzheimer’s disease 0.000792 Parkinson’s disease 0.00261 Pathways in cancer 0.00315 Hypertrophic cardiomyopathy (HCM) 0.00594 Small cell lung cancer 0.00677 Prostate cancer 0.00721	Measles 0.000463 Toxoplasmosis 0.000463 Herpes simplex infection 0.000578 Staphylococcus aureus infection 0.00246 Pertussis 0.000000000000612 Tuberculosis 0.00000000000987 Leishmaniasis 0.0000000254 Influenza A 0.0000000563 Malaria 0.000000086 Salmonella infection 0.0000000885 Legionellosis 0.000000137 Chagas disease (American trypanosomiasis) 0.00000033 Amoebiasis 0.000000376 African trypanosomiasis 0.000000412 Staphylococcus aureus infection 0.0000997 Measles 0.000305 Toxoplasmosis 0.000305 Hepatitis C 0.00291 HTLV-I infection 0.00604 Herpes simplex infection 0.00858