Toxoplasmosis and Polygenic Disease Susceptibility Genes: Extensive Toxoplasma gondii Host/Pathogen Interactome Enrichment in Nine Psychiatric or Neurological Disorders

Table 3

A Statistical analysis of the overlap between human genes in the T. gondii Interactome, and the susceptibility genes in various diseases. The number of susceptibility genes analysed (𝑁 genes) is shown for each disease, together with the observed and expected values for each condition, the fold and mean enrichments, and the 𝑃 value derived from the chi squared test.

Disease	𝑁 Genes	% involved in T. gondii interactome	Condition	Observed	Expected	Enrichment (fold)	Mean enrichment (A + B)/2	𝑃 value
Multiple Sclerosis	408	32.5	Susceptibility genes in interactome (A)	135	54.6	2.47	2.83	1.22𝐸−71
			Interactome genes in disease dataset (B)	135	42.4	3.18
Alzheimer's	432	27.3	Susceptibility genes in interactome	118	57.8	2.04	2.33	2.26𝐸−41
			Interactome genes in disease dataset	118	44.9	2.63
Schizophrenia	759	21.1	Susceptibility genes in interactome	160	101.6	1.57	1.80	3.06𝐸−27
			Interactome genes in disease dataset	160	78.9	2.03
Bipolar disorder	443	21.2	Susceptibility genes in interactome	94	59.3	1.58	1.81	5.36𝐸−17
			Interactome genes in disease dataset	94	46.05	2.04
Depression	221	23.5	Susceptibility genes in interactome	52	29.6	1.76	2.01	2.41𝐸−13
			Interactome genes in disease dataset	52	22.97	2.26
Childhood obesity	73	31.5	Susceptibility genes in interactome	23	9.77	2.35	2.69	2.32𝐸−12
			Interactome genes in disease dataset	23	7.58	3.03
Parkinson's disease	263	19.7	Susceptibility genes in interactome	52	35.21	1.47	1.69	3.82𝐸−08
			Interactome genes in disease dataset	52	27.34	1.90
ADHD	237	17.7	Susceptibility genes in interactome	42	31.73	1.32	1.51	8.01𝐸−05
			Interactome genes in disease dataset	42	24.63	1.70
Autism	1117	12.7	Susceptibility genes in interactome	142	149.55	0.95	1.08	0.013
			Interactome genes in disease dataset	142	116.13	1.22
Anorexia	74	16.2	Susceptibility genes in interactome	12	9.91	1.21	1.38	0.09
			Interactome genes in disease dataset	12	7.69	1.55
Chronic Fatigue	95	12.6	Susceptibility genes in interactome	12	12.72	0.94	1.08	0.48
			Interactome genes in disease dataset	12	9.87	1.21