Review Article
A Comprehensive Review of Hypertension in Pregnancy
Table 3
Observations supporting uteroplacental ischemia as a key factor in preeclampsia.
| (i) predominantly occurs in primagravidas with immature uterine vasculature | (ii) consistent abnormalities of the placentae and uteroplacental vascular interface | (iii) increased risk with more fetuses and placentas (twins) | (iv) disease occurs late in gestation | (v) labor aggravates | (vi) high incidence with large, rapidly growing hydatidiform moles | (vii) increase incidence in patients with underlying vascular disease (diabetes, hypertension and lupus (SLE)) | (viii) findings in animals subjected to uteroplacental ischemia mimic those of preeclampsia |
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