Review Article
A Roadmap to the Brittle Bones of Cystic Fibrosis
Table 2
Cystic fibrosis foundation guidelines for treatment of osteoporosis.
| | General Recommendations |
| Vitamin D goal | 25OH Vit D level >75 nmol/L or 30 ng/mL |
| Calcium | 1300–1500mg/day |
| Vitamin K | 0.3–0.5 mg/day |
| Target BMI | >50th percentile | BMI adult females 23 | BMI adult males 22 |
| Exercise | Encourage outdoor and weight bearing exercise |
| Infections | Aggressive treatment of pulmonary infections |
| | Specific Recommendations by T/Z Score |
| | T/Z score ≤ −2 | −1≤ T/Z score ≤ −2 | T/Z scores ≥ −1.0 |
| Repeat DEXA | Annual | Repeated every 2–4 years | Repeated every 5 years |
| Steroid | Minimize steroid doses | No recommendation |
| Endocrine |
Recognize and treat CF related diabetes, delayed puberty, hypogonadism, and consider endocrine consult | No recommendation |
| Bisphosphonate | Start bisphosphonate | If fragility fracture, patient awaiting transplant or accelerated BMD loss >3-5% per year start bisphosphonate | No recommendation |
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