A little over two years ago, a hot new topic in retinal imaging caught the attention of ophthalmologists around the world. Optical coherence tomography angiography (OCTA), an innovative, fast, noninvasive, non-dye-based angiographic technique, quickly became a topic of great interest in major conferences and ophthalmology journals. Inquisitive minds applied the OCTA prototypes to understanding diseases such as macular degeneration, diabetic retinopathy, and glaucoma. The technology’s high resolution and ability to segment the different vascular layers provided novel insight into disease pathogenesis and morphology. However, as with any new technology, it had limitations such as image artifact and the inability to accurately quantify vascular parameters. Today, advancements in software that address some of the limitations and more widespread access to the OCTA devices allow investigators to further expand upon our collective knowledge of ophthalmologic disease.

The purpose of this special issue is to publish a collection of innovative and high-quality research articles and reviews addressing the application of OCTA to retinal diseases. We invite investigators to submit original research articles and reviews to this special issue.

Potential topics include but are not limited to the following:

• Reviews of the utility of OCTA in various retinal diseases
• Changes in vasculature or neovascularization over time
• Effect of treatment on vascular structures
• Quantitative assessment or techniques
• Novel processing or analysis
• Diabetic retinopathy
• Age-related macular degeneration
• Inherited retinal disease
• Retinal artery occlusion
• Retinal vein occlusion
• Ocular tumors