Journal of Ophthalmology

Myopia: Risk Factors, Disease Mechanisms, Diagnostic Modalities, and Therapeutic Options


Status
Published

1Medical University of Bialystok, Bialystok, Poland

2Poznan University of Medical Sciences, Poznan, Poland

3Medical University of Silesia, Katowice, Poland

4Medical University of Vienna, Vienna, Austria


Myopia: Risk Factors, Disease Mechanisms, Diagnostic Modalities, and Therapeutic Options

Description

Myopia is a global problem, being particularly prevalent in the urban areas of east and southeast Asia. It is estimated that 2.5 billion people will be affected by myopia within the next decade. In addition to the economic and social burdens, associated ocular complications may lead to visual impairment. Myopia has a diverse etiology, with both environmental and genetic factors believed to be involved in the myopia’s development and progression. Genetic linkage studies have mapped the dozen loci, while association studies have found more than 70 different genes. Many of these genes are involved in common biological pathways to known to mediate extracellular matrix composition and regulate connective tissue remodelling. Other associated genomic regions suggest novel mechanisms in the etiology of high myopia, such as mitochondrial-mediated cell death and photoreceptor-mediated visual signal transmission. The environmental factors implicated in myopia include near work, light exposure, lack of physical activity, diet, a higher level of education, and urbanization. The interactions between genes and environmental factors may be significant in determining individual risks of high myopia and may help explain the pathogenetic mechanisms of myopia in human population.

In the past years, various techniques had been used to study ocular blood in myopia, such as fluorescein angiography (FA), indocyanine green angiography (ICGA), color Doppler imaging (CDI), optical coherence tomography (OCT), and optical coherence tomography angiography (OCTA). These tools provide a noninvasive and quantitative approach for monitoring choroidal and retinal changes in pathologic myopia. OCTA especially is an imaging technique that enables high-speed, high-resolution, and depth-resolved imaging of the retinal and choroidal vasculatures in myopia related complications diagnosis such as chorioretinal atrophy and choroidal neovascularization (CNV).

Most nearsighted patients see marked improvement with treatment including corrective lenses, corneal refractive therapy, and refractive surgery. Early treatment of myopia can prevent social and academic difficulties that can accompany poor vision.

We invite investigators to contribute high quality research papers as well as review articles addressing recent advances on risk factors, disease mechanisms, diagnostic modalities, and therapeutic options in myopia.

Potential topics include but are not limited to the following:

  • Genetic and environmental factor in myopia
  • Pathogenetic mechanisms in the development of myopia
  • New insight on diagnostic modalities
  • Myopic tractional maculopathy including foveoschisis, lamellar macular hole, and macular retinal detachment
  • Ocular blood flow parameters in myopia
  • Myopic choroidal neovascularization
  • Advances in prevention of myopia
  • Insight on surgical and nonsurgical techniques for treatment of myopia
  • Current approaches to refractive corrections of myopia

Articles

  • Special Issue
  • - Volume 2018
  • - Article ID 7942379
  • - Editorial

Myopia: Risk Factors, Disease Mechanisms, Diagnostic Modalities, and Therapeutic Options

Malgorzata Mrugacz | Marzena Gajecka | ... | Katarzyna J. Witkowska
  • Special Issue
  • - Volume 2018
  • - Article ID 1686045
  • - Research Article

Internal Astigmatism and Its Role in the Growth of Axial Length in School-Age Children

Liangcheng Wu | Chenghai Weng | ... | Xingtao Zhou
  • Special Issue
  • - Volume 2018
  • - Article ID 5076454
  • - Research Article

Myopia Progression Risk: Seasonal and Lifestyle Variations in Axial Length Growth in Czech Children

Stepan Rusnak | Vaclav Salcman | ... | Zdenek Kasl
  • Special Issue
  • - Volume 2018
  • - Article ID 9197631
  • - Research Article

Effect of Altered Retinal Cones/Opsins on Refractive Development under Monochromatic Lights in Guinea Pigs

Leilei Zou | Xiaoyu Zhu | ... | Jinhui Dai
  • Special Issue
  • - Volume 2018
  • - Article ID 2181602
  • - Research Article

Choroidal and Retinal Thickness of Highly Myopic Eyes with Early Stage of Myopic Chorioretinopathy: Tessellation

Yanping Zhou | Minlu Song | ... | Xiaodong Sun
  • Special Issue
  • - Volume 2018
  • - Article ID 4680603
  • - Review Article

Early Intervention and Nonpharmacological Therapy of Myopia in Young Adults

Katarzyna Zorena | Aleksandra Gładysiak | Daniel Ślęzak
  • Special Issue
  • - Volume 2018
  • - Article ID 3490962
  • - Research Article

The Comparison of Regional RNFL and Fundus Vasculature by OCTA in Chinese Myopia Population

Yuanjun Li | Hamza Miara | ... | Bing Jiang
  • Special Issue
  • - Volume 2018
  • - Article ID 3150923
  • - Research Article

Long-Term Natural Outcomes of Simple Hemorrhage Associated with Lacquer Crack in High Myopia: A Risk Factor for Myopic CNV?

Bing Liu | Xiongze Zhang | ... | Feng Wen
  • Special Issue
  • - Volume 2018
  • - Article ID 4694789
  • - Review Article

Modern Diagnostic Techniques for the Assessment of Ocular Blood Flow in Myopia: Current State of Knowledge

Ewa Grudzińska | Monika Modrzejewska
  • Special Issue
  • - Volume 2018
  • - Article ID 9781987
  • - Research Article

Prevalence and Related Factors for Myopia in School-Aged Children in Qingdao

Jin Tao Sun | Meng An | ... | Da Bo Wang
Journal of Ophthalmology
 Journal metrics
Acceptance rate37%
Submission to final decision93 days
Acceptance to publication38 days
CiteScore1.780
Impact Factor1.580
 Submit