Regulation of the Inflammatory Response, Proliferation, Migration, and Epithelial-Mesenchymal Transition of Human Lens Epithelial Cells by the lncRNA-MALAT1/miR-26a-5p/TET1 Signaling Axis

Figure 2

Differentially expressed lncRNAs are found in the anterior capsular tissues of HMC and ARC patients. (a) The total number of increased and decreased lncRNAs detected in HMC samples compared with the ARC group. (b) Volcano plots filtering differentially upregulated and downregulated lncRNAs with statistical significance (log2 fold change ≥1.5,  < 0.05). (c) Expressions of MALAT1, SOS2, SLIT2, ID3, PPP4R2, and SIPA1L1 were most increased. (d) The clustered heatmap showing MALAT1 expression was significantly higher in HMC samples than in the ARC group. (e) RT-qPCR detected MALAT1 expression that was markedly higher in HMC samples. GAPDH served as the endogenous control.

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