Research Article
BIBF1120 Protects against Diabetic Retinopathy through Neovascularization-Related Molecules and the MAPK Signaling Pathway
Figure 6
BIBF1120 suppresses the tube formation, migration, and proliferation of HRMECs in vitro. (a) The proliferation capability of HRMECs measured by an EdU assay. The EdU‐positive cell ratio was analyzed (red: proliferating cells, blue (DAPI): nucleus, scale = 200 μm). (b) Scratch test to detect the migration of HRMECs (scale bar = 20 μm). (c) A the migration capability of HRMECs detected by a transwell assay (scale bar = 20 μm). The number of migrated cells was counted. (d) The number of closed tubes obtained by a tube formation assay (scale bar = 100 μm). vs. the normal group; ### vs. high glucose group. DMSO: dimethyl sulfoxide; EdU: 5‐ethynyl‐20‐deoxyuridine.
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