Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect Keratoconus and Suspect Keratoconus

Table 5

Sensitivity, specificity, and area under the curve values identified by cutoff points of different epithelial thickness parameter sets to differentiate eyes with suspect keratoconus from normal corneas and keratoconus from normal ones.

Epithelial thickness (μm)	Cutoff value		AUC		Sensitivity (%)		Specificity (%)
	Normal vs. SKC	Normal vs. KC	Normal vs. SKC	Normal vs. KC	Normal vs. SKC	Normal vs. KC	Normal vs. SKC	Normal vs. KC
Min ET (0_2)	≤48	≤42	0.65	0.96	83.72	94.12	37.7	93.4
Avg ET (0_2)	≤48	≤47	0.63	0.85	58.14	85.29	65.6	75.4
Max ET (0_2)	≤49	≤49	0.56	0.6	51.16	52.94	68.9	68.9
Min-Max ET (0_2)	≤−5	≤−6	0.69	0.96	51.16	94.12	83.6	88.5
Min ET (2_5)	≤48	≤41	0.65	0.94	83.72	91.18	37.7	85
Avg ET (2_5)	≤48	≤46	0.63	0.65	58.14	55.88	65.6	76.7
Max ET (2_5)	≤49	>54	0.56	0.7	51.16	58.82	68.9	73.3
Min-Max ET (2_5)	≤−9	≤−12	0.71	0.95	67.44	97.06	76.7	88.3
S-I ET (2_5)	>0	>1	0.63	0.88	39.53	76.47	85	91.7
SN-IT ET (2_5)	>0	>4	0.69	0.96	62.79	88.24	66.7	96.7
CET	≤48	≤43	0.63	0.85	55.81	55.88	65.6	98.4

Min = minimum; ET = epithelial thickness; Avg = average; Max = maximum; Min-Max = minimum-maximum; S-I = superior-inferior; SN-IT = superonasal-inferotemporal; CET = central epithelial thickness; AUC = area under the receiver operating characteristic curve; SKC = suspect keratoconus; KC = keratoconus. Criteria of all variables had units of μm.