Diagnostic Accuracy of Corneal and Epithelial Thickness Map Parameters to Detect Keratoconus and Suspect Keratoconus
Table 4
Sensitivity, specificity, and area under the curve values identified by cutoff points of different OCT-based corneal thickness parameter sets to differentiate eyes with suspect keratoconus from normal corneas and keratoconus from normal ones.
Pachymetry (μm)
Cutoff value
AUC
Sensitivity (%)
Specificity (%)
Normal vs. SKC
Normal vs. KC
Normal vs. SKC
Normal vs. KC
Normal vs. SKC
Normal vs. KC
Normal vs. SKC
Normal vs. KC
Min CT (0_2)
≤526
≤478
0.75
0.88
88.37
82.86
57.4
83.6
Avg CT (0_2)
≤535
≤497
0.74
0.85
86.05
82.35
54.1
78.7
Max CT (0_2)
≤557
≤526
0.75
0.8
88.37
76.47
50.8
73.8
Min-Max CT (0_2)
≤−26
≤−32
0.68
0.94
53.49
94.12
86.9
93.4
Min CT (2_5)
≤537
≤493
0.75
0.88
95.35
91.18
50.8
77.1
Avg CT (2_5)
≤581
≤542
0.73
0.78
100
91.18
36.1
60.7
Max CT (2_5)
≤613
≤608
0.72
0.72
90.7
91.18
49.2
50.8
Min-Max CT (2_5)
≤−77
≤−77
0.61
0.89
41.86
91.18
41.9
82
S-I CT (2_5)
>1
>15
0.58
0.77
95.35
90.62
23
59
SN-IT CT (2_5)
>25
>35
0.66
0.83
74.42
78.12
50.8
82
CCT
≤533
≤491
0.76
0.87
86.05
82.35
55.7
83.6
Min = minimum; CT = corneal thickness; Avg = average; Max = maximum; Min-Max = minimum-maximum; S-I = superior-inferior; SN-IT = superonasal-inferotemporal; CCT = central corneal thickness; AUC = area under the receiver operating characteristic curve; SKC = suspect keratoconus; KC = keratoconus.
