Research Article
Modulation of Hypoxia-Inducible Factors and Vascular Endothelial Growth Factor Expressions by Superfood Camu-Camu (Myrciaria dubia) Treatment in ARPE-19 and Fetal Human RPE Cells
Figure 2
Inhibitory hypoxia-inducible factor (HIF) activity effects of camu-camu. Camu-camu was evaluated at various concentrations. (a, b) Quantitative analyses of the HIF-reporter luciferase assay using RH-ARPE19 cells (n = 3 per group, biological). Camu-camu was added from 1 to 1000 μg/mL each. HIF activity induced by 200 μM CoCl2. HIF activity was not induced in the control group. ### compared with no treatment. and compared with MQ by 200 μM of CoCl2 treatment. (a) Relative luciferase activity reflecting HIF-1α activity. (b) Relative Renilla activity reflecting cell viability. The bar graphs present means with ± standard deviation. The data were analyzed using two-tailed Student’s t-test for comparison. MQ: Milli-Q® water; Topo: topotecan; DXR: doxorubicin.
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