Efficacy of Nonpreserved Sodium Hyaluronate Artificial Tears in Dry Eye Disease Patients Treated with Prostaglandin Analogs for Primary Open-Angle Glaucoma: A Prospective, Nonrandomized, Open-Label Pilot Study
Table 2
Summary statistics for secondary outcomes by time.
Outcome
Visit time
N
Mean (standard deviation)
valuea
Score
Paired difference with baseline
OSDI
Baseline
30
37.7 (18.1)
4 weeks
30
29.9 (17.8)
−7.8 (16.7)
0.02
12 weeks
30
29.6 (18.8)
−8.1 (20.7)
0.04
TBUT (seconds)
Baseline
30
4.7 (3.1)
4 weeks
30
6.1 (3.8)
1.5 (3.6)
0.01
12 weeks
30
4.9 (1.9)
0.2 (2.5)
0.40
CFS
Baseline
30
5.4 (3.6)
4 weeks
30
3.3 (2.4)
−2.1 (2.8)
<0.001
12 weeks
30
0.9 (1.4)
−4.5 (4.0)
<0.001
Schirmer test (mm)
Baseline
30
13.6 (7.4)
12 weeks
30
15.7 (5.1)
2.1 (5.7)
0.05
aOne-sample signed rank-sum test or 1-samplet-test as appropriate. Abbreviations: CFS, corneal fluorescein staining; OSDI, Ocular Surface Disease Index; TBUT, tear film break-up time.
