Research Article

Alterations in Parafoveal and Optic Disc Vessel Densities in Patients with Obstructive Sleep Apnea Syndrome

Table 2

Comparison of the age and sex corrected IOP, CMT, RNFL, and GCC thicknesses of OSAS groups with healthy controls using generalized estimating equation models.

Control (n = 27, 54 eyes)Mild OSAS (n = 27, 54 eyes)Moderate OSAS (n = 24, 48 eyes)Severe OSAS (n = 26, 52 eyes)

BCVA (Snellen)0.94 ± 0.0850.96 ± 0.08
−0.003
−0.049/0.042
(0.885)
0.94 ± 0.08
0.015
−0.028/0.059
(0.490)
0.94 ± 0.09
0.004
−0.043/0.058
(0.848)

IOP (mmHg)12.13 ± 1.0213.11 ± 2.25
0.072
−0.431/0.535
(0.779)
13.58 ± 1.85
0.827
−0.695/1.340
(0.065)
13.91 ± 1.96
1.151
0.765/1.73
(0.001)

CMT261.57 ± 41.40267.01 ± 24.26
5.444
−9.979/20.869
(0.489)
265.70 ± 22.12
4.128
−10.990/19.246
(0.593)
259.50 ± 24.43
−2.074
−17.752/13.374
(0.792)

Average RNFL (μ)109.52 ± 11.57103.73 ± 8.98
−2.788
−8.030/2.455
(0.297)
100.23 ± 10.55
−5.284
−11.484/−0.920
(0.095)
99.26 ± 12.06
−6.249
−12.398/−0.100
(0.046)

Superior RNFL (μ)129.12 ± 18.17128.30 ± 16.15
0.178
−7.899/8.255
(0.966)
122.10 ± 19.61
−7.023
−16.237/2.191
(0.135)
124.19 ± 19.75
−4.937
−14.131/4.256
(0.293)

Nasal RNFL (μ)79.34 ± 18.3277.97 ± 15.98
2.439
−5.377/10.254
(0.541)
76.90 ± 17.30
1.071
−6.517/8.659
(0.782)
71.69 ± 15.24
−5.215
−12.646/2.216
(0.169)

Inferior RNFL (μ)137.92 ± 20.06132.98 ± 14.87
−4.945
−13.287/3.393
(0.245)
126.0 ± 19.17
−9.464
−19.322/0.393
(0.060)
124.46 ± 21.53
−11.926
−21.329/−2.216
(0.013)

Temporal RNFL (μ)78.90 ± 15.1469.11 ± 9.93
−4.290
−11.991/3.410
(0.245)
64.61 ± 11.85
−6.580
−13.213/0.520
(0.052)
62.32 ± 10.94
−9.792
−15.529/−4.055
(0.001)

GCC superior (μ)111.40 ± 9.32107.40 ± 9.33
−2.004
−7.272/3.265
(0.456)
103.89 ± 6.75
−5.514
−10.324/0.703
(0.025)
103.70 ± 9.37
−5.504
−11.028/3.813
(0.041)

GCC inferior (μ)110.98 ± 11.64106.57 ± 10.64
−2.405
−8.076/3.267
(0.406)
103.44 ± 8.96
−5.535
−10.806/−0.214
(0.040)
101.75 ± 17.45
−7.231
−13.991/−0.472
(0.031)

OSAS: obstructive sleep apnea syndrome; BCVA: best-corrected visual acuity; IOP: intraocular pressure; CMT: central macular thickness; RNFL: retinal nerve fiber layer; GCC: ganglion cell complex. values of comparisons between the control group are represented within parentheses.