Journal of Ophthalmology / 2020 / Article / Tab 3 / Clinical Study
Systemic Factors Associated with Treatment Response in Diabetic Macular Edema Table 3 Association of various systemic factors with change in central subfield thickness (CST) and change in logMAR visual acuity (N = 33), (Mann–Whitney U test).
S/N Systemic factor Reduction in CST valueChange in logMAR visual acuity valueMean SD Mean SD 1 IHD No (n = 23) 98.43 165.38 0.3371 0.013 0.239 0.7479 Yes (n = 10) 44.3 105.23 0.006 0.193 2 On dialysis No (n = 30) 77.63 145.77 0.7542 0.006 0.234 0.2105 Yes (n = 3) 126 222.7 0.06 0.053 3 Systolic BP ≤140 (n = 11) 71.73 180.23 0.4337 −3.05 0.29 0.09532 >140 (n = 22) 87.18 137.18 0.016 0.192 4 Diastolic BP ≤90 (n = 29) 79.31 155.30 0.6994 0.283 0.228 0.1492 <90 (n = 4) 101.75 122.09 −0.115 0.160 5 Creatinine ≤120 (18) 77.61 134.9 0.6255 −0.008 0.212 0.2582 <120 (n = 15) 87.3 171.47 0.033 0.243 6 eGFR >90 (n = 8) 82.13 172.0 0.8831 0.058 0.267 0.7961 <90 (n = 25) 82 146.44 −0.004 0.212 6 Total cholesterol ≤5.2 (n = 24) 72.67 147.39 0.7464 −0.018 0.197 0.2905 >5.2 (n = 9) 107.25 163.7 0.087 0.283 7 Triglycerides </ = 2.2 (n = 22) 91.14 166.77 0.9239 0.054 0.244 0.1645 >2.2 (n = 11) 63.82 114.99 −0.075 0.153 8 HDL cholesterol ≥1 (n = 27) 69.67 134.7 0.7794 0.002 0.208 0.6322 <1 (n = 6) 137.67 213.2 0.05 0.307 9 LDL cholesterol </ = 3.3 (n = 25) 69.76 145.02 0.5015 −0.017 0.192 0.2627 >3.3 (n = 8) 120.38 169.67 0.098 0.301 10 LDL: total cholesterol ≤3.5 (n = 14) 41.86 75.49 0.8841 −0.054 0.157 0.5558 >3.5 (n = 19) 111.63 183.86 0.059 0.256 11 HbA1c ≤7 (n = 15) 130.13 158.44 0.012 0.001 0.259 0.8821′ >7 (n = 18) 41.94 134.32 0.019 0.197 12 Serum VEGF ≤308 (n = 10) 41.1 132.49 0.1894 0.008 0.065 0.6879 >308 (n = 23) 99.83 156.64 0.012 0.267
CST, central subfield thickness; IHD, ischemic heart disease; BP, blood pressure; eGFR, estimated glomerular filtration rate; HDL, high-density lipoprotein; LDL, low-density lipoproteins; HbA1c, glycosylated hemoglobin; VEGF, vascular endothelial growth factor.