Clinical Role of Epigenetics and Network Analysis in Eye Diseases: A Translational Science Review

Figure 2

A network-oriented workflow. The computational pipeline relies on four steps: (1) sample preparation (patients vs controls), (2) whole-genome bisulfite sequencing, weighted coexpression network analysis (WGCNA), (3) constriction of network-based maps, and (4) validation and predictions. These epigenetic biomarkers and correlated interactomes may divide DR patients into precise groups, thereby improving personalized therapy.