Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
Influence of diabetes and VEGFR1 blockade on gene expression of cytokines and chemokines. The differentially expressed genes between diabetic and nondiabetic retina were identified by cytokine and chemokine PCR arrays each group. The STZ-induced diabetic mice (3 months diabetes duration) and nondiabetic mice of the same age were used for this experiment. (a) Upregulated genes by diabetes. (b) Downregulated genes by diabetes. (c) Genes whose expression was affected by MF1 treatment were quantified by real-time PCR ( each group). (d) The table showed the fold changes of gene expression between diabetic and nondiabetic mice and between MF1 treatment and rat IgG treatment. The results were the mean value of log2 (fold changes) ± SD (). Induction means that the gene was detected only in the diabetic mouse retina but not in the nondiabetic mouse retina.
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