Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
Inhibition of diabetes-caused BRB breakdown by VEGFR1 blockade. Nondiabetic mice and STZ-induced diabetic mice that were treated with rat IgG or MF1 were used for quantitative BRB assay. The diabetic duration was 3 months (or 13 weeks) and the total time of rat IgG or MF1 treatment was 39 (3 times/week). The CPM reading of retina, lung, or kidney was normalized by its own tissue mass (CPM/mg). RLLR (retina to lung leakage ratio) and RRLR (retina to renal leakage ratio). The results were averaged from 5 mice (). .
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