Blockade of Vascular Endothelial Growth Factor Receptor 1 Prevents Inflammation and Vascular Leakage in Diabetic Retinopathy
Increased expression of VEGFR1 protein in the retina of STZ-induced mice. The STZ-induced diabetic mice with 3 or 6 months of diabetes duration were used for this analysis. (a) Western blots (WB) results. β-Actin was used for loading control. (b) The WB quantification results . versus nondiabetic controls. ((c) and (d)) IF results showed that VEGFR1 protein localized in the blood vessels of the diabetic mouse retina (d) but was not detected in the nondiabetic control mouse retina (c). GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer plexiform layer. Scale bar: 50 μm.
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