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| Eid et al. SOARD 2005 [16] | Stroh et al. Zentralbl Chir 2008 (paper in German, abstract in English) [13] | Doblado et al. Ferti Steril 2010 [19] | Jamal et al. SOARD 2012 [17] | Talebpour Obes Surg 2011 (abstract only) [18] | George and Azeez Obes Surg 2013 (abstract only) [20] |
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Participants | 24 women with PCOS | 3 females with PCOS | 2 females with infertility secondary to PCOS (and to male factor) | 10 women with PCOS and infertility | 69 premenopausal married females | 156 women (67 had radiological features of PCOS and 11 were infertile) |
Interventions | Laparoscopic RYGB | Laparoscopic LAGB | RYGB and gastric band, respectively | RYGB | Gastric plication or RYGB | Laparoscopic SG |
Outcomes measured | Mean excess weight loss, presence of hirsutism, regular menstruation, conception rate after surgery, obesity associated comorbidities | % EWL, glucose levels, conception rate | Conception and pregnancy | Pre- and postsurgery conception rate, weight loss, hirsutism, menstrual dysfunction, obesity associated comorbidities | Regularity of menstruation and conception rate | Hirsutism, stress urinary incontinence, menstrual dysfunction, infertility |
Study design | Retrospective | Not stated | Retrospective | Retrospective | Not stated | Retrospective |
Mean follow-up (months) | | 104 | Not stated | | 12 | Not stated |
Results, fertility | 5 women (previously infertile) who wanted to conceive were able to do so after surgery without the use of clomiphene | One patient (33%) conceived postoperatively | Following IVF/ICSI, both women became pregnant and had uncomplicated deliveries | 100% postoperative conception rate in infertile patients with PCOS who desired pregnancy | 10 women (71%) out of 14 who were infertile preoperatively became pregnant after one year postoperatively | 4 patients (36%) conceived without any formal fertility treatment |
Results – other | Resolution of T2D, decreased number of patients with hypertension and hyperlipidemia, improvement of PCOS-associated symptoms | The 3 patients had a % EWL of 49, 67, and 41%, respectively, with glucose levels normalized postoperatively | | Improvement of glycemic control, PCOS-associated symptoms, hypertension, depression, GERD, and urinary incontinence | Out of 30 patients with irregular cycles preoperatively, 14 (47%) had regular cycles by the end of 1 year postoperatively | Hirsutism and radiological evidence of PCOS resolved in 80%; menstrual dysfunction improved in 100%; urinary incontinence resolved or improved in 42% |
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