Research Article

Obesity and Metabolic Phenotypes (Metabolically Healthy and Unhealthy Variants) Are Significantly Associated with Prevalence of Elevated C-Reactive Protein and Hepatic Steatosis in a Large Healthy Brazilian Population

Table 1

Baseline population characteristics according to metabolic status and obesity.

Metabolically fealthy normal weight ()Metabolically unhealthy normal weight ()Metabolically healthy overweight/obese ()Metabolically unhealthy overweight/obese () values (between group differences)

Age (yrs)41 ± 946 ± 1043 ± 947 ± 10<0.001
Male (%)1100 (59%)209 (80%)1731 (85%)1264 (92%)<0.001
Metabolic syndrome determinants
 BMI (kg/m2)22.58 ± 1.7323.47 ± 1.2527.97 ± 2.8529.70 ± 3.74<0.001
 Systolic BP (mm Hg)112 ± 10121 ± 13119 ± 10128 ± 13<0.001
 Diastolic BP (mm Hg)73 ± 777 ± 877 ± 782 ± 7<0.001
 Glucose (mg/dL)85 ± 890 ± 989 ± 894 ± 14<0.001
 Triglycerides (mg/dL)*89 (69–117)183 (145–236)107 (82–137)189 (154–245)<0.001
 HDL (mg/dL)55 ± 1440 ± 949 ± 1139 ± 9<0.001
 Hypertension139 (7%)116 (45%)397 (20%)919 (67%)<0.001
 Diabetes/↑FPG7 (<1%)12 (5%)13 (<1%)183 (13%)<0.001
 Dyslipidemia462 (25%)256 (98%)700 (35%)1344 (98%)<0.001
Anthropometric data
 Waist (cm)81 ± 786 ± 696 ± 9102 ± 10<0.001
 Waist hip ratio 0.84 ± 0.070.90 ± 0.060.92 ± 0.070.96 ± 0.06<0.001
Other variables
 Total cholesterol (mg/dL)199 ± 33208 ± 41208 ± 37214 ± 41<0.001
 Non-HDL (mg/dL)143 ± 35168 ± 42159 ± 37175 ± 40<0.001
 LDL (mg/dL)124 ± 31129 ± 35136 ± 33134 ± 35<0.001
 AST (IU/L)28 ± 1030 ± 932 ± 1134 ± 12<0.001
 ALT (IU/L)29 ± 1536 ± 1640 ± 2246 ± 24<0.001
 GGT (IU/L)29 ± 2139 ± 2641 ± 3752 ± 47<0.001
 hs-CRP*0.8 (0.5–1.6)1.1 (0.6–2.2)1.4 (0.8–2.7)1.7 (1.0–3.0)<0.001
Presence of steatosis (%)152 (8%)70 (27%)805 (40%)952 (70%)<0.001
Elevated CRP (%)223 (12%)44 (17%)452 (22%)343 (25%)<0.001

Data expressed as median (interquartile range).