Colorectal cancer is one of the tumor types in which individualized therapy has been successfully applied with significant improvement of survival rates in the last decade. Despite new drugs used in oncological regimens, some patients still do not respond to therapy and second or third line options are necessary. Moreover, secondary resistance to chemotherapeutics or molecular antibodies is a daily challenge for oncologists.

The aim of this Special Issue is to confer an update of the molecular profile of colorectal cancer cells, as a starting point for exploration of the future through the light of molecular pathology. As the targeted therapy is based on the individualized genetic profile, understanding changes related to the tumor cell, at tissue level or in the blood flow, is the only possibility for improving therapeutics. Original research and reviews are welcome.

Potential topics include but are not limited to the following:

• Molecular profile of circulating tumor cells
• Liquid biopsies and potential future follow-up
• Immunohistochemical assessment of tumor cells profile
• Tumor and inflammatory biomarkers involved in diagnosis and evolution of colorectal carcinoma
• Serum vs tissue biomarkers
• Digitalized quantification of cancer cell activity
• The use of bioinformatics in diagnosing colorectal cancer
• Carcinogenesis and metastatic potential of tumor cells
• Prognostic and predictive parameters
• Experimental and clinical studies aimed to detect the particularities of the tumor environment
• Epithelial mesenchymal transition
• Challenges and opportunities of screening programs
• Molecular-targeted therapy and clinical trials
• New concepts in angiogenesis