The growth, invasion, and metastasis of malignant tumors require the formation of neovascularization. Tumor angiogenesis requires activation and proliferation of endothelial cells, degradation of the basement membrane, and extension of endothelial cells outwards in a cable shape. In addition, tumor angiogenesis is also mediated by multiple vascular growth factors and vascular growth inhibition factors. The angiogenesis of tumor metastasis has complex molecular mechanisms.

However, the in-depth regulatory mechanism of tumor angiogenesis and its role in tumor metastasis remain to be further studied and reported. Tumors grow slowly by having no blood vessels to provide a blood supply. Tumor cells then release a variety of angiogenic factors that alter the original morphology of vascular endothelial cells. The basement membrane and extracellular matrix are degraded, and endothelial cells proliferate and migrate, forming and remodeling blood vessels. At present, anti-angiogenesis has become one of the new methods to treat tumors. In conclusion, the process of tumor progression and metastasis is extremely complex. Tumor metastasis is caused by the mutual regulation and interaction of many aspects, many stages, and many molecules.

We welcome original submissions and review articles to this Special Issue with the aim to develop understanding in this field. In-depth understanding of the molecular mechanisms of angiogenesis in tumor metastasis would be helpful to lay a solid molecular biological foundation for the clinical treatment of tumor metastasis. It also opens up a new milestone for the comprehensive treatment of tumors.

Potential topics include but are not limited to the following:

• Tumor vasculogenic mimicry
• Regulation mechanism of tumor angiogenesis
• Mechanism study of anti-tumor angiogenesis drugs
• Review on the progress of anti-tumor angiogenesis drugs
• The role of non-coding RNA in tumor angiogenesis and vascular metastasis
• The role of traditional chinese medicine molecules in inhibiting tumor angiogenesis and hematologic metastasis
• Regulation mechanism of tumor angiogenesis factors