FGFR4 c.1162G > A (p.Gly388Arg) Polymorphism Analysis in Turkish Patients with Retinoblastoma

Table 3

Association of FGFR4 p.Gly388Arg variant with family history.

Family history	Wild-type GG no. (%)	Heterozygous GA no. (%)	Homozygous AA no. (%)	Total no. (%)	Significance, p value
RB in family
Yes	0 (0%)	3 (13.6%)	0 (0%)	3 (6.1%)	0.08
No	22 (100%)	19 (86.4%)	5 (100%)	46 (93.9%)
Total	22	22	5	49
OT in family
Yes	16 (72.7%)	16 (72.7%)	4 (80%)	36 (73.5%)	0.94
No	6 (27.3%)	6 (27.3%)	1 (20%)	13 (26.5%)
Total	22	22	5	49
RAOG in family
Yes	12 (54.5%)	14 (63.6%)	5 (100%)	31 (63.3%)	0.07
No	10 (45.5%)	8 (36.4%)	0 (0%)	18 (36.7%)
Total	22	22	5	49

Wild-type GG allele; c.[1162G > G]; [1162G > G], heterozygous GA allele; c. [1162G > G]; [1162G > A], homozygous AA; c. [1162G > G]; [1162A > A]. RB, retinoblastoma; OT, other tumors (brain tumor, breast cancer, lung cancer, thyroid cancer, and prostate cancer); RAOG, risk assessment of occupational groups.