Somatic Mutations in <i>HER2</i> and Implications for Current Treatment Paradigms in <i>HER2</i>-Positive Breast Cancer

<div>The mechanism of action of different drugs (italics and striped) on HER receptor signaling pathways. HER: human epidermal growth factor receptor; MAPK: mitogen-activated protein kinase; PI3K: phosphatidylinositol 3-kinase; Akt: serine/threonine kinase Akt, also known as PKB (protein kinase B); ECD: extracellular domain; TMD: transmembrane domain; TKD: tyrosine kinase domain.</div>

Journal of Oncology

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Figure 2: Somatic Mutations in <i>HER2</i> and Implications for Current Treatment Paradigms in <i>HER2</i>-Positive Breast Cancer 

Journal of Oncology

Somatic Mutations in HER2 and Implications for Current Treatment Paradigms in HER2-Positive Breast Cancer

Figure 2