TY - JOUR A2 - Kanat, Ozkan AU - Huber, Matthew AU - Huber, Brian PY - 2019 DA - 2019/11/23 TI - Innovation in Oncology Drug Development SP - 9683016 VL - 2019 AB - Significant progress has been made in our understanding of the molecular lesions responsible for tumor cells to exhibit uncontrolled growth while circumventing normal mechanisms of apoptosis and their ability to migrate and invade normal tissues while evading recognition and destruction by the immune system. This understanding has enabled the development of therapies specifically targeted to these lesions coupled to innovative treatment regimens to most effectively use these new targeted therapies with precision in selected subpopulations of patients. Innovation at the scientific and clinical levels has been appropriately embraced and supported at the FDA, resulting in regulatory innovation to facilitate and adapt to the Precision Medicine environment. SN - 1687-8450 UR - https://doi.org/10.1155/2019/9683016 DO - 10.1155/2019/9683016 JF - Journal of Oncology PB - Hindawi KW - ER -