| Roles in cancer | Cancer types | miR-221/222 | Target genes | References |
| Onco-miRNA | Glioblastoma | Both | puma | [31] | Gastric cancer | miR-222 | reck, hipk2 | [32, 33] | Both | pten | [34] | Bladder cancer | miR-222 | ppp2r2a | [35] | Lung cancer | miR-222 | socs3, ppp2r2a | [36, 37] | Liver cancer | miR-221 | p27, p57, ddit4, bmf, hdac6, adipor1, erα, caspase-3, socs3 | [38–46] | miR-222 | ppp2r2a, gnai3, bbc3, pbx3 | [47–50] | Both | pten, timp3, p27 | [29, 51] | Colorectal cancer | miR-221 | p27, p57, pten, tp53inp1, reck | [49, 52, 53] | miR-222 | pten, mst3, mia3 | [54–56] | Both | p27, p57, pten, pdlim2 | [57, 58] | Breast cancer | miR-221 | A20 | [59] | Both | erα, esr1, mybl1, cdkn1b, bim, cdkn1c, pten, timp3, ddit4 | [60–63] | Cervical cancer | miR-221 | vash1, thbs | [64, 66] | miR-222 | p27, pten | [67] | Both | timp3 | [68] | Ovarian cancer | miR-221 | apaf1, bmf, | [69, 70] | miR-222 | p27, socs3, gnai2 | [71, 72] | Both | p57, pten | [66, 73] | Endometrial carcinoma | miR-222 | erα | [74] | Melanoma | Both | p27, c-kit | [75, 76] | Pancreatic cancer | miR-222 | p27 | [77] | Thyroid cancer | Both | p27, pten | [78–79] | Multiple myeloma | miR-221 | p27kip1 | [80] | Chronic lymphocytic leukemia | Both | p27 | [81] | Oral carcinoma | Both | p27 | [82] | Retinoblastoma | Both | ap2α | [83] | Nasopharyngeal carcinoma | miR-222 | pten | [84] | Prostate carcinoma | Both | p27 | [85] |
| Tumor suppressor miRNA | Prostate cancer | Both | ecm29 | [61] | Erythroleukemia | Both | kit | [86] | Gastrointestinal stromal tumors | Both | kit | [87] | Tongue squamous cell carcinoma | miR-222 | mmp1, sod2 | [88] | Cholangiocarcinoma | miR-221 | pik3r1 | [89] | Ovarian cancer | miR-221 | arf 4 | [90] | miR-222 | gnai 2 | [91] | Colorectal cancer | miR-222 | adam-17 | [92] | Medulloblastoma | miR-221 | eif5a2 | [93] |
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