Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches

<div>Summary of the genes identified with SNVs in matched initial and recurrent <i>IDH</i><sup><i>WT</i></sup> (<i>n</i> = 7) and <i>IDH</i><sup><i>MUT</i></sup> diffuse tumours (<i>n</i> = 1; case 8). Genes are arranged hierarchically within their pathways for the RTK/Ras/PI(3)K (red), IDH (yellow), NOTCH, SHH, and WNT signalling (variations of green), p53 (blue), Rb (purple), and G-proteins (dark blue) pathways. Numbers across the top axis denote the patient identifier; “a” and “b” indicate initial and recurrent tumours, respectively.</div>

Journal of Oncology

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Figure 2: Clinically Actionable Insights into Initial and Matched Recurrent Glioblastomas to Inform Novel Treatment Approaches 