Polymorphisms in Survivin (BIRC5 Gene) Are Associated with Age of Onset in Breast Cancer Patients

Table 4

Association of genotype and allele frequencies of polymorphisms with age of onset.

polymorphism			mean±SD (years)	p-value
c.-1547C>T	genotype	CC	62.3±6.5	0.054
		CT	55.8±8.1
		TT	49.0±10.1
	allele	C	58.3±7.9	0.011
		T	50.9±9.8
c.-644T>C	genotype	TT	59.4±8.2	0.006
		TC	50.7±8.6
		CC	39.0±2.8
	allele	T	55.8±9.2	0.006
		C	48.1±9.1
c.-241C>T	genotype	CC	54.7±10.0	0.143
		CT	49.0±4.5
		TT	37.0±0.0
	allele	C	54.2±9.6	0.029
		T	45.0±7.1
c.9386T>C	genotype	TT	49.1±9.3	0.029
		TC	57.4±8.4
		CC	62.3±6.5
	allele	T	50.8±9.6	0.004
		C	59.5±7.6
c.9809T>C	genotype	TT	59.4±8.2	0.006
		TC	50.7±8.6
		CC	39.0±2.8
	allele	T	55.8±9.2	0.006
		C	48.1±9.1

C is the minor allele.