Polymorphisms in Survivin (BIRC5 Gene) Are Associated with Age of Onset in Breast Cancer Patients
Table 3
Comparison of minor allele frequencies of BIRC5 polymorphisms between breast cancer patients and healthy control samples. Nucleotide changes are named according to the literature.
gene region
SNP ID number
nucleotide change
minor allele frequency controls (n/N, %)
minor allele frequency BC samples (n/N, %)
p (for allele frequencies)
promoter
rs3764383
c.-1547C>T
37/148 (25.0)
16/52 (30.8)
0.466
promoter
rs8073903
c.-644T>C
49/148 (33.1)
18/52 (34.6)
0.865
promoter
rs8073069
c.-625G>C
33/148 (22.3)
13/52 (25.0)
0.704
promoter
rs17878731
c.-267G>A
1/148 (0.7)
1/52 (1.9)
0.453
promoter
rs17878467
c.-241C>T
16/148 (10.8)
6/52 (11.5)
1.000
promoter
rs17887126
c.-235G>A
2/148 (1.3)
0/52 (0)
5'UTR
rs9904341
c.-31G>C
55/148 (37.2)
18/52 (34.6)
0.867
intron 2
rs4789551
c.221+209T>C
7/148 (4.7)
1/52 (1.9)
0.683
exon 4
rs2071214
c.9194G>A
5/148 (3.4)
1/52 (1.9)
1.000
3'UTR
rs17885521
c.9288G>C
3/148 (2.0)
1/52 (1.9)
1.000
3'UTR
rs17882627
c.9342G>A
2/148 (1.3)
2/52 (3.8)
0.278
3'UTR
rs2239680
c.9386T>C
34/148 (23.0)
14/52 (26.9)
0.575
3'UTR
rs17882139
c.9387_9388insAA
3/148 (2.0)
2/52 (3.8)
0.606
3'UTR
rs1042489
c.9809T>C
53/148 (35.8)
18/52 (34.6)
1.000
3'UTR
rs2661694
c.10611C>A
38/148 (25.7)
11/52 (21.1)
0.578
n – number of minor alleles, N – number of analyzed alleles C is the minor allele G is the minor allele.
