Polymorphisms in Survivin (BIRC5 Gene) Are Associated with Age of Onset in Breast Cancer Patients

Figure 4

Pairwise linkage disequilibrium (LD) of eight BIRC5 sequence variants with highest minor allele frequency. The location of each sequence variant along the BIRC5 gene is relative to the real nucleotide position. The number in each diamond indicates the intensity of LD (r²) between respective pairs of sequence variants. The LD strength is also represented by shades of grey (0 [white] < r² < 1 [black]). (a) Controls. (b) Cases.

(a)

(b)