Mutated WT1, FLT3-ITD, and NUP98-NSD1 Fusion in Various Combinations Define a Poor Prognostic Group in Pediatric Acute Myeloid Leukemia

Figure 4

Prognostic significance of NUP98-NSD1 fusion. (a) NUP98-NSD1 as single factor predicted poor outcomes. (b) Inclusion of NUP98-NSD1 as poor prognostic factor with WT1 mutation and FLT3-ITD, predicted poor outcomes for patients harboring all three factors in addition to patients with NUP98-NSD1 and WT1 mutation or FLT3-ITD. Patients with unknown status of NUP98-NSD1 fusion were excluded from this analysis. WT1, Wilms Tumor 1; FLT3-ITD, fms related tyrosine kinase 3-internal tandem duplication; NUP98-NSD1, Nucleoporin-Nuclear Receptor Binding SET Domain Protein 1 fusion gene; pEFS, probability of event-free survival; pOS, probability of overall survival; CIR, cumulative incidence of relapse; SE, standard error; mut, mutated; pos, positive; neg, negative. No response to treatment was considered as the occurrence of an event at time zero. Three patients with NUP98-NSD1 are included in this group.