Mutated WT1, FLT3-ITD, and NUP98-NSD1 Fusion in Various Combinations Define a Poor Prognostic Group in Pediatric Acute Myeloid Leukemia

Figure 3

Mutations in NPM1, NRAS, and c-KIT had no impact on survival. (a) Prognostic impact of mutated NPM1 on EFS, OS, and CIR. (b) Prognostic impact of mutated NRAS on EFS, OS, and CIR. (c) Prognostic impact of c-KIT mutation on EFS, OS, and CIR. NPM1, nucleophosmin 1; NRAS, neuroblastoma RAS viral oncogene homolog; c-KIT, KIT protooncogene; pEFS, probability of event-free survival; pOS, probability of overall survival; CIR, cumulative incidence of relapse; SE, standard error; n, number. No response to treatment was considered as the occurrence of an event at time zero.